CodY is a global regulator of virulence-associated properties for Clostridium perfringens type D strain CN3718.

doi:10.1128/mBio.00770-13

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Article

CodY is a global regulator of virulence-associated properties for Clostridium perfringens type D strain CN3718.

mBio - 8 Oct 2013

Li Jihong, Ma Menglin, Sarker Mahfuzur R, McClane Bruce A

Abstract excerpt

UNLABELLED: CodY is known to regulate various virulence properties in several Gram-positive bacteria but has not yet been studied in the important histotoxic and intestinal pathogen Clostridium perfringens. The present study prepared an isogenic codY-null mutant in C. perfringens type D strain CN3718 by insertional mutagenesis using the Targetron system. Western blot analysis indicated that, relative to wild-type...

Topics

Animals
Bacterial Proteins
Bacterial Toxins
Caco-2 Cells
Clostridium Infections
Clostridium perfringens
Dogs
Gene Expression Regulation, Bacterial
Genes, Regulator
Humans
Mutation
Transcription Factors
Virulence

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Identifiers

PMID: 24105766
DOI: 10.1128/mBio.00770-13
PMCID: PMC3791898

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