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Article

Diversity of human p53 mutants revealed by complex formation to SV40 T antigen.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1992

Bártek J, Vojtĕsek B, Lane D P

Abstract excerpt

The products of the two major suppressor genes p53 and Rb interact with the oncogene products of the DNA tumour viruses. These viral-host protein interactions mimic and interfere with the normal interactions of p53 and Rb with host proteins. The Rb gene product is frequently mutated in human cancers such that it no longer binds to viral or host proteins. In contrast we find that this is not the case with p53 as...

Topics

Antigen-Antibody Complex
Antigens, Polyomavirus Transforming
Genes, Retinoblastoma
Genes, p53
Genetic Variation
Humans
Mutation
Oncogene Proteins, Viral
Protein Binding
Simian virus 40
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1332735
DOI: 10.1016/0959-8049(93)90584-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1332735-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Diversity of human p53 mutants revealed by complex formation to SV40 T antigen.PMID 1332735Read ↗

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