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Article

Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell lines.

Genes, chromosomes & cancer - 1 Jul 1992

van der Bosch K, Becker I, Savelyeva L, Brüderlein S, Schlag P, Schwab M

Abstract excerpt

Cytogenetic analyses of human colon cancer cells have revealed non-random deletions in chromosome arm 8p, among other chromosomal changes. By using 8p-specific DNA probes we could identify allelic loss in 87% of colon cancer cell lines. Corresponding analyses in direct preparations of colon tumor tissues revealed a minimal value of 40% of allelic loss but were obstructed in many instances by contaminating normal...

Topics

Alleles
Chromosome Deletion
Chromosomes, Human, Pair 8
Colorectal Neoplasms
DNA Probes
DNA, Neoplasm
Genetic Markers
Humans
Tumor Cells, Cultured

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1384668
DOI: 10.1002/gcc.2870050114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1384668-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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