Functional and clinical significance of variants localized to 8q24 in colon cancer.

doi:10.1158/1055-9965.EPI-09-0362

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Article

Functional and clinical significance of variants localized to 8q24 in colon cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2009

Cicek Mine S, Slager Susan L, Achenbach Sara J, French Amy J, Blair Hilary E, Fink Stephanie R, Foster Nathan R, Kabat Brian F, Halling Kevin C, Cunningham Julie M, Cerhan James R, Jenkins Robert B, Boardman Lisa A, Petersen Gloria M, Sargent Daniel J, Alberts Steven R, Limburg Paul J, Thibodeau Stephen N

Abstract excerpt

Multiple genome-wide association studies have identified several susceptibility variants for colon cancer at 8q24. However, the functional roles of these variants have yet to be elucidated. Here, we evaluated the potential role of these markers in tumor progression and examined association with commonly observed structural abnormalities in this region, c-MYC amplification and chromosome fragility at FRA8C and...

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PMID: 19690179
DOI: 10.1158/1055-9965.EPI-09-0362
PMCID: PMC4059694

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Functional and clinical significance of variants localized to 8q24 in colon cancer.PMID 19690179Read ↗

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