Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma.

doi:10.1038/sj.onc.1202648

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Article

Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma.

Oncogene - 20 May 1999

Pineau P, Nagai H, Prigent S, Wei Y, Gyapay G, Weissenbach J, Tiollais P, Buendia M A, Dejean A

Abstract excerpt

The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromosome 8p in HCC, we have undertaken high-density polymorphic marker analysis of 109 paired normal and primary tumor...

Topics

Adult
Alleles
Base Sequence
Carcinoma, Hepatocellular
Chromosome Deletion
Chromosomes, Human, Pair 8
DNA Primers
Female
Humans
Liver Neoplasms
Loss of Heterozygosity
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 10340384
DOI: 10.1038/sj.onc.1202648

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