Article
Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.
The Journal of experimental medicine - 1 Jan 1995
Lehner P J, Wang E C, Moss P A, Williams S, Platt K, Friedman S M, Bell J I, Borysiewicz L K
Abstract excerpt
The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL) response is important in the clearance of viral infections in humans. After influenza A infection, a peptide from the matrix protein, M58-66, is presented in the context of the MHC allele HLA-A0201 and the resulting CTL response is detectable in most HLA-A0201 subjects. An initial study suggested that M58-66-specific CTL clones...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- CD8-Positive T-Lymphocytes
- Clone Cells
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genes, MHC Class I
- HLA-A Antigens
- Humans
- Immunologic Memory