Article
Mutations in E.coli 16s rRNA that enhance and decrease the activity of a suppressor tRNA.
Nucleic acids research - 11 Apr 1992
Prescott C D, Kornau H C
Abstract excerpt
The in vivo expression of mutations constructed within helix 34 of 16S rRNA has been examined together with a nonsense tRNA suppressor for their action at stop codons. The data revealed two novel results: in contrast to previous findings, some of the rRNA mutations affected suppression at UAA and UAG nonsense codons. Secondly, both an increase and a decrease in the efficiency of the suppressor tRNA were induced...
Topics
- Base Sequence
- Binding Sites
- Codon
- Escherichia coli
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Bacterial
- RNA, Ribosomal, 16S
- RNA, Transfer