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Article

Functional interaction between release factor one and P-site peptidyl-tRNA on the ribosome.

Journal of molecular biology - 16 Aug 1996

Zhang S, Rydén-Aulin M, Isaksson L A

Abstract excerpt

Translation termination at UAG is influenced by the nature of the 5' flanking codon in Escherichia coli. Readthrough of the stop codon is always higher in a strain with mutant (prfA1) as compared to wild-type (prfA+) release factor one (RF1). Isocodons, which differ in the last base and are decoded by the same tRNA species, affect termination at UAG differently in strains with mutant or wild-type RF1. No general...

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Identifiers

PMID: 8757279
DOI: 10.1006/jmbi.1996.0444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional interaction between release factor one and P-site peptidyl-tRNA on the ribosome.PMID 8757279Read ↗

Functional interaction between tRNA2Gly2 at the ribosomal P-site and RF1 during termination at UAG.Semantic proximity Read ↗

Interaction between a mutant release factor one and P-site peptidyl-tRNA is influenced by the identity of the two bases downstream of the stop codon UAG.Semantic proximity Read ↗

Efficient decoding of the UAG triplet as a full-fledged sense codon enhances the growth of a prfA-deficient strain of Escherichia coli.Semantic proximity Read ↗

R213I mutation in release factor 2 (RF2) is one step forward for engineering an omnipotent release factor in bacteria Escherichia coli.Semantic proximity Read ↗

A novel mutation in ribosomal protein S4 that affects the function of a mutated RF1.Semantic proximity Read ↗

Genetic implication for an interaction between release factor one and ribosomal protein L7/L12 in vivo.Semantic proximity Read ↗

Release factor one is nonessential in Escherichia coli.Semantic proximity Read ↗

Amber (UAG) suppressors affected in UGA/UAA-specific polypeptide release factor 2 of bacteria: genetic prediction of initial binding to ribosome preceding stop codon recognition.Semantic proximity Read ↗

Ribosomes containing the C1054-deletion mutation in E. coli 16S rRNA act as suppressors at all three nonsense codons.Semantic proximity Read ↗

Codon and base biases after the initiation codon of the open reading frames in the Escherichia coli genome and their influence on the translation efficiency.Semantic proximity Read ↗

The involvement of base 1054 in 16S rRNA for UGA stop codon dependent translational termination.Semantic proximity Read ↗

Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.Semantic proximity Read ↗

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