Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.

doi:10.1073/pnas.0706558104

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Article

Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2007

Ejby Morten, Sørensen Michael A, Pedersen Steen

Abstract excerpt

Escherichia coli strains with inactivated rluD genes were previously found to lack the conserved pseudouridines in helix 69 of 23S ribosomal RNA and to grow slowly. A suppressor mutant was isolated with a near normal growth rate that had changed the conserved Glu-172 codon to a Lys codon in prfB, encoding translation termination factor RF2. When nonsense suppression in strains with all combinations of...

Topics

Codon, Nonsense
Escherichia coli
Escherichia coli Proteins
Hydro-Lyases
Mutation
Nucleic Acid Conformation
Peptide Chain Termination, Translational
Peptide Termination Factors
Phenotype
Pseudouridine
RNA, Ribosomal, 23S
Suppression, Genetic

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Identifiers

PMID: 18032607
DOI: 10.1073/pnas.0706558104
PMCID: PMC2148303

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