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Article

Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2007

Ejby Morten, Sørensen Michael A, Pedersen Steen

Abstract excerpt

Escherichia coli strains with inactivated rluD genes were previously found to lack the conserved pseudouridines in helix 69 of 23S ribosomal RNA and to grow slowly. A suppressor mutant was isolated with a near normal growth rate that had changed the conserved Glu-172 codon to a Lys codon in prfB, encoding translation termination factor RF2. When nonsense suppression in strains with all combinations of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18032607
DOI: 10.1073/pnas.0706558104
PMCID: PMC2148303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.PMID 18032607Read ↗

Inactivation of the RluD pseudouridine synthase has minimal effects on growth and ribosome function in wild-type Escherichia coli and Salmonella enterica.Semantic proximity Read ↗

An Alternative Role of RluD in the Fidelity of Translation Initiation in Escherichia coli.Semantic proximity Read ↗

Mutations in helix 34 of Escherichia coli 16 S ribosomal RNA have multiple effects on ribosome function and synthesis.Semantic proximity Read ↗

A pseudouridine synthase required for the formation of two universally conserved pseudouridines in ribosomal RNA is essential for normal growth of Escherichia coli.Semantic proximity Read ↗

The involvement of base 1054 in 16S rRNA for UGA stop codon dependent translational termination.Semantic proximity Read ↗

Conserved Pseudouridines in Helix 69 of the Ribosome are Important for Ribosome Dynamics in TranslationSemantic proximity Read ↗

Novel UGA-suppressors in Escherichia coli K-12.Semantic proximity Read ↗

Ribosomes containing the C1054-deletion mutation in E. coli 16S rRNA act as suppressors at all three nonsense codons.Semantic proximity Read ↗

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Ribosomal protein L11 mutations in two functional domains equally affect release factors 1 and 2 activity.Semantic proximity Read ↗

Variety of nonsense suppressor phenotypes associated with mutational changes at conserved sites in Escherichia coli ribosomal RNA.Semantic proximity Read ↗

Sequence and functional analysis of mutations in the gene encoding peptide-chain-release factor 2 of Escherichia coli.Semantic proximity Read ↗

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