Article
Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones.
Virology - 20 Jul 2007
Mylin Lawrence M, Schell Todd D, Epler Melanie, Kusuma Caroline, Assis David, Matsko Chelsea, Smith Alexandra, Allebach April, Tevethia Satvir S
Abstract excerpt
To better understand the relationship between epitope variation and tumor escape from immune surveillance, SV40 T antigen-transformed B6/K-0 cells were subjected to selection with individual CTL clones specific for the SV40 T antigen H-2D(b)-restricted epitopes I or V. CTL-resistant populations were isolated from a majority of the selection cultures and substituted epitope sequences were identified within most of...
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