Identification of single amino acid substitutions in the staphylococcal nuclease protein that enhance and diminish T cell clone recognition of naturally processed peptides.

doi:10.1093/intimm/4.12.1399

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Article

Identification of single amino acid substitutions in the staphylococcal nuclease protein that enhance and diminish T cell clone recognition of naturally processed peptides.

International immunology - 1 Dec 1992

Finnegan A, Regan J, Seamon K B, Lindholm C

Abstract excerpt

It has been inferred that residue changes that affect T cell recognition of synthetic peptides will have a similar effect in the intact protein. However, since small peptides do not require antigen processing it is possible that residue changes in synthetic peptides will not have an equivalent ef...

Topics

Amino Acids
Animals
Clone Cells
Immunodominant Epitopes
Male
Mice
Mice, Inbred C57BL
Micrococcal Nuclease
Mutation
Peptide Fragments
T-Lymphocytes

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