Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.

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Article

Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.

International journal of radiation biology - 1 Dec 1994

Cole J, Arlett C F

Abstract excerpt

The mutant frequency at the hprt locus in circulating T-lymphocytes has been determined in 16 ataxia-telangiectasia (A-T) patients, 19 A-T heterozygotes and 12 A-T sibs. Mutant frequency in the A-T patients is highly significantly elevated as a group, even when the relatively poor cloning efficie...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Ataxia Telangiectasia
Child
Child, Preschool
Cloning, Molecular
Female
Genetic Heterogeneity
Heterozygote
Humans
Hypoxanthine Phosphoribosyltransferase
Infant
Infant, Newborn
Male
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 7836839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7836839-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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