Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.

International journal of radiation biology - 1 Dec 1994

Cole J, Arlett C F

Abstract excerpt

The mutant frequency at the hprt locus in circulating T-lymphocytes has been determined in 16 ataxia-telangiectasia (A-T) patients, 19 A-T heterozygotes and 12 A-T sibs. Mutant frequency in the A-T patients is highly significantly elevated as a group, even when the relatively poor cloning efficiency of many of the A-T lymphocyte samples is taken into account. However, within the A-T set, considerable variation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Cloning, Molecular

Share to Heterozygote

Share to Mutation

Source

Identifiers

PMID: 7836839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.PMID 7836839Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients.Semantic proximity Read ↗

Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations.Semantic proximity Read ↗

Reduced proliferation rate of hypoxanthine-phosphoribosyl transferase mutant human T-lymphocytes in vitro.Semantic proximity Read ↗

hprt mutations in vivo in human T-lymphocytes: frequencies, spectra and clonality.Semantic proximity Read ↗

Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity.Semantic proximity Read ↗

Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants.Semantic proximity Read ↗

In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes.Semantic proximity Read ↗

An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets.Semantic proximity Read ↗

Ataxia-telangiectasia: closer to unraveling the mystery.Semantic proximity Read ↗

Genetic instability in human T-lymphocytes.Semantic proximity Read ↗

The development of a differential assay for the determination of ataxia-telangiectasia heterozygosity in human subjectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.