Article

The tryptophan catabolite or kynurenine pathway in a major depressive episode with melancholia, psychotic features and suicidal behaviors; a systematic review and meta-analysis

2022-08-07

Abstract excerpt

<h4>Background</h4> Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic features and suicidal behaviors are accompanied by activated immune-inflammatory and oxidative pathways which may stimulate indoleamine 2,3- dioxygenase (IDO), the first and rate-limiting enzyme of the tryptophan catabolite (TRYCAT) pathway resulting in increased tryptophan degradation and elevated tryptop...

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Literature Corpus work: bd9097ce-f608-5c8a-aa1e-00af4c0fa85f
DOI: 10.1101/2022.08.06.22278492

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