Article
Higher incidence of p53 mutation in cervical carcinomas with intermediate-risk HPV infection.
European journal of obstetrics, gynecology, and reproductive biology - 1 Oct 2001
Kim H J, Song E S, Hwang T S
Abstract excerpt
OBJECTIVE: Inactivation of p53, either through mutation or interaction with human papillomavirus (HPV) E6 oncoprotein, is a characteristic feature of cervical carcinoma cell lines that have been previously studied. To elucidate the role of p53 in the carcinogenesis of Korean cervical carcinomas, 27 HPV-positive and 13 HPV-negative cervical carcinomas were studied in order to evaluate the status of the p53 gene....
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