Association of TP53 codon 72 and intron 3 16-bp Ins/Del polymorphisms with cervical cancer risk.

doi:10.1007/s13277-014-1988-8

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Article

Association of TP53 codon 72 and intron 3 16-bp Ins/Del polymorphisms with cervical cancer risk.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2014

Laprano Tatiana Dantas Rodrigues, Lemos Erika Hardy, Cunha Lia Moreira Pinto, Júnior José Eleutério, de SousaTeles Rosiane Alves, Rabenhorst Silvia Helena Barem

Abstract excerpt

Cervical cancer incidence has grown worldwide, with it being a more significant problem in developing countries. Invasive squamous cell cervical cancers are preceded by a long phase of preinvasive disease, known as cervical intraepithelial neoplasia. Cervical cancer can develop when the virus takes advantage of any TP53 gene dysfunction of the host organism. TP53 is responsible for encoding the tumor suppressor...

Topics

Adolescent
Adult
Codon
Female
Genes, p53
Genetic Predisposition to Disease
Humans
Introns
Middle Aged
Polymorphism, Genetic
Risk
Uterine Cervical Neoplasms
Uterine Cervical Dysplasia

Source

Open in PubMed

Identifiers

PMID: 24782034
DOI: 10.1007/s13277-014-1988-8

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