Article
Establishment of cytotoxic CD4+ T cell clones from cancer patients treated by local immunotherapy.
Biotherapy (Dordrecht, Netherlands) - 1 Jan 1992
Nagaoka H, Monden T, Sakita I, Katsumoto Y, Wakasugi T, Kawasaki Y, Tomita N, Takeda T, Yagyu T, Morimoto H
Abstract excerpt
We have previously reported that the antitumor effect of OK-432, a Streptococcal preparation, is markedly augmented when injected intratumorally together with fibrinogen (Cancer, 69: 636-642, 1992). In order to elucidate the mechanism of the antitumor effects, we established T cell clones from regional lymph nodes of colorectal cancer patients who received this local immunotherapy. By culture of lymph node...
Topics
- CD4-Positive T-Lymphocytes
- Cell Adhesion Molecules
- Clone Cells
- Colorectal Neoplasms
- Flow Cytometry
- Humans
- Immunohistochemistry
- Immunotherapy
- Intercellular Adhesion Molecule-1
- Lymph Nodes