Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of cytotoxic CD4+ T cell clones from cancer patients treated by local immunotherapy.

Biotherapy (Dordrecht, Netherlands) - 1 Jan 1992

Nagaoka H, Monden T, Sakita I, Katsumoto Y, Wakasugi T, Kawasaki Y, Tomita N, Takeda T, Yagyu T, Morimoto H

Abstract excerpt

We have previously reported that the antitumor effect of OK-432, a Streptococcal preparation, is markedly augmented when injected intratumorally together with fibrinogen (Cancer, 69: 636-642, 1992). In order to elucidate the mechanism of the antitumor effects, we established T cell clones from regional lymph nodes of colorectal cancer patients who received this local immunotherapy. By culture of lymph node...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Clone Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Flow Cytometry

Share to TNF gene

Share to Immunohistochemistry

Share to Phenotype

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 1363274
DOI: 10.1007/BF02179041

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of cytotoxic CD4+ T cell clones from cancer patients treated by local immunotherapy.PMID 1363274Read ↗

Augmentation of antitumor immunity in regional lymph nodes by local immunotherapy.Semantic proximity Read ↗

The concurrent administration of OK432 augments the antitumor vaccination effect with tumor cells by sustaining locally infiltrating natural killer cells.Semantic proximity Read ↗

Efficacy of in vitro sensitized cells generated by in vivo priming with OK-432 for adoptive immunotherapy of the poorly immunogenic B16-Bl6 melanoma.Semantic proximity Read ↗

OK-432 develops CTL and LAK activity in mononuclear cells from regional lymph nodes of lung cancer patients.Semantic proximity Read ↗

Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.Semantic proximity Read ↗

Effective strategy of dendritic cell-based immunotherapy for advanced tumor-bearing hosts: the critical role of Th1-dominant immunity.Semantic proximity Read ↗

Effects of OK-432 on the proliferation and cytotoxicity of lymphokine-activated killer (LAK) cells.Semantic proximity Read ↗

Effects of OK-432 on in vitro secondary responses of the non-adherent cells to IL-2 and OK-432 in cancer patients without tumor burden.Semantic proximity Read ↗

HLA-B-restricted, CD8+ cytolytic human T cell clones derived from a melanoma-invaded lymph node.Semantic proximity Read ↗

Generation of cytotoxic T lymphocytes from peripheral blood.Semantic proximity Read ↗

Effect of anti-CD3 antibody on the generation of interleukin-2-activated lymphocytes from tumor tissues of gastrointestinal cancer.Semantic proximity Read ↗

Fibronectin promotes the proliferation of cytotoxic T lymphocytes generated from cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.