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Article

Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Oshikawa Tetsuya, Okamoto Masato, Tano Tomoyuki, Sasai Akiko, Kan Shin, Moriya Yoichiro, Ryoma Yoshiki, Saito Motoo, Akira Shizuo, Sato Mitsunobu

Abstract excerpt

OK-432 is a Streptococcus-derived immunotherapeutic agent for malignancies. Our group has tried to identify the effective components of OK-432 and has succeeded in isolating a lipoteichoic acid-related preparation designated as OK-PSA, which is a strong inducer of T helper 1 (T(H)1) cells, and elicits an anticancer effect via Toll-like receptor (TLR) 4. Conversely, bacterial DNA with unmethylated CpG motifs can...

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Source

Identifiers

PMID: 16531815
DOI: 10.1097/01.cji.0000189028.18288.6f

Genes

TLR9
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.PMID 16531815Read ↗

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