Article
The concurrent administration of OK432 augments the antitumor vaccination effect with tumor cells by sustaining locally infiltrating natural killer cells.
Cancer immunology, immunotherapy : CII - 1 Sept 1996
Kurosawa S, Harada M, Shinomiya Y, Terao H, Nomoto K
Abstract excerpt
The effect of a local injection with a streptococcal preparation OK432 on the antitumor vaccination with tumor cells was investigated. Natural killer (NK) cells, which were detected by anti-NK1.1 monoclonal antibody (mAb), increased in the peritoneal exudate cells after an intraperitoneal (i.p.)...
Topics
- Adoptive Transfer
- Animals
- Exudates and Transudates
- Female
- Injections, Intraperitoneal
- Interferon-gamma
- Killer Cells, Lymphokine-Activated
- Killer Cells, Natural
- Kinetics
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Neoplasms
- Peritoneal Cavity
- Phenotype
- Picibanil
- Spleen
- Stimulation, Chemical