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Article

Effects of OK-432 on the proliferation and cytotoxicity of lymphokine-activated killer (LAK) cells.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 1999

Yamamoto K, Tanaka R, Yoshida S, Ono K, Mori H, Taniguchi Y, Oda T, Watanabe T

Abstract excerpt

We studied the effect of a streptococcal preparation, OK-432, on the cytotoxicity and the proliferation of lymphokine-activated killer (LAK) cells for use in adoptive immunotherapy. Peripheral blood mononuclear cells (PBMC) were derived from healthy donors and patients with malignant brain tumors. We divided PBMC into two groups; these cells then were stimulated with interleukin-2 in the presence or absence of...

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Identifiers

PMID: 9924697
DOI: 10.1097/00002371-199901000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Effects of OK-432 on the proliferation and cytotoxicity of lymphokine-activated killer (LAK) cells.PMID 9924697Read ↗

Effects of OK-432 on in vitro secondary responses of the non-adherent cells to IL-2 and OK-432 in cancer patients without tumor burden.Semantic proximity Read ↗

Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.Semantic proximity Read ↗

Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432.Semantic proximity Read ↗

OK-432 develops CTL and LAK activity in mononuclear cells from regional lymph nodes of lung cancer patients.Semantic proximity Read ↗

The effects of cytokine-induced killer cells for the treatment of patients with solid tumors: a clinical retrospective study.Semantic proximity Read ↗

Streptococcal preparation OK432 promotes functional maturation of human monocyte-derived dendritic cells.Semantic proximity Read ↗

[The effect of corticosteroid on lymphokine-activated killer (LAK) activity and the change of membrane antigen phenotype on PBMC after IL2 incubation with reference to the evaluation in vitro].Semantic proximity Read ↗

Gamma-irradiated peripheral blood mononuclear cells can express LAK activity.Semantic proximity Read ↗

Interference of the induction of suppressor cells by a streptococcal preparation, OK-432 through the blocking of suppressor inducer T-cells.Semantic proximity Read ↗

Profile of T-cell receptor V beta gene usage of cytotoxic T cells induced by intrapleural administration of a streptococcal preparation, OK432, in malignant effusions.Semantic proximity Read ↗

In-vitro effects of cyclosporin A, FK506, 6-mercaptopurine, and prednisolone on lymphokine-activated killer cells.Semantic proximity Read ↗

Effect of culture media on lymphokine-activated killer effector phenotype and lytic capacity.Semantic proximity Read ↗

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