Article
Effects of OK-432 on the proliferation and cytotoxicity of lymphokine-activated killer (LAK) cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 1999
Yamamoto K, Tanaka R, Yoshida S, Ono K, Mori H, Taniguchi Y, Oda T, Watanabe T
Abstract excerpt
We studied the effect of a streptococcal preparation, OK-432, on the cytotoxicity and the proliferation of lymphokine-activated killer (LAK) cells for use in adoptive immunotherapy. Peripheral blood mononuclear cells (PBMC) were derived from healthy donors and patients with malignant brain tumors...
Topics
- Antigens, CD
- Antineoplastic Agents
- Brain Neoplasms
- Cell Division
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Drug
- Flow Cytometry
- Humans
- Immunotherapy, Adoptive
- Interleukin-2
- Killer Cells, Lymphokine-Activated
- Leukocytes, Mononuclear
- Lymphocyte Activation
- Phenotype
- Picibanil
- Receptors, Interleukin-2