Augmentation of antitumor immunity in regional lymph nodes by local immunotherapy.

doi:10.1007/BF01877423

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Article

Augmentation of antitumor immunity in regional lymph nodes by local immunotherapy.

Biotherapy (Dordrecht, Netherlands) - 1 Jan 1993

Sakita I, Monden T, Nagaoka H, Katsumoto Y, Wakasugi T, Tomita N, Takeda T, Kobayashi T, Shimano T, Mori T

Abstract excerpt

We have previously reported that the antitumor effect of OK-432, a streptococcal preparation, is markedly augmented when injected intratumorally together with fibrinogen (OK-432/fbg) [1]. In order to elucidate the effects of this immunotherapy on regional lymph nodes (RLN), we carried out both mo...

Topics

Aged
Colonic Neoplasms
Combined Modality Therapy
Female
Fibrinogen
Flow Cytometry
Humans
Killer Cells, Lymphokine-Activated
Killer Cells, Natural
Lymph Nodes
Lymphocyte Activation
Lymphocytes
Male
Middle Aged
Phenotype
Picibanil

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Open in PubMed

Identifiers

PMID: 8398569
DOI: 10.1007/BF01877423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8398569-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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