Article
Polymorphisms of a scrapie-associated fibril protein (PrP) gene and their association with susceptibility to experimentally induced scrapie in Cheviot sheep in the United States.
American journal of veterinary research - 1 Oct 1992
Maciulis A, Hunter N, Wang S, Goldmann W, Hope J, Foote W C
Abstract excerpt
The duration of the incubation period for scrapie, a fatal transmissible neurodegenerative disorder of sheep and goats, is mainly determined by the Sip gene, which has 2 alleles (sA--susceptible and pA--resistant). A diagnostic test is not available to detect scrapie in live animals. We analyzed genomic DNA extracted from frozen sheep brains collected from Cheviot sheep of the United States that had been...
Topics
- Animals
- DNA
- Genetic Markers
- Genetic Predisposition to Disease
- Polymorphism, Restriction Fragment Length
- PrPSc Proteins
- Prions
- Scrapie
- Sheep
- Survival Rate
- United States