Article
Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.
The Journal of general virology - 1 Oct 1991
Goldmann W, Hunter N, Benson G, Foster J D, Hope J
Abstract excerpt
The incubation period of scrapie in sheep is controlled by the Sip gene which has two alleles (sA and pA). Following experimental challenge with SSBP/1 scrapie, a short incubation period is conferred by the partially dominant sA allele. Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene are associated with the Sip alleles. By sequencing the protein coding region of the...
Topics
- Alleles
- Animals
- Arginine
- Base Sequence
- DNA, Viral
- Genotype
- Glycine
- Haplotypes
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length
- PrPSc Proteins