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Article

PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.

Genomics - 1 Jan 1993

Laplanche J L, Chatelain J, Westaway D, Thomas S, Dussaucy M, Brugere-Picoux J, Launay J M

Abstract excerpt

Scrapie is a transmissible degenerative disease of the central nervous system occurring naturally in sheep and goats. An abnormal protease-resistant form of the host-encoded prion protein (PrP) accumulates in the brains of affected animals. As Sip, a gene controlling the incubation period of experimental and natural scrapie, is linked to the single-copy sheep PrP gene, we sought PrP coding sequence polymorphisms...

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Identifiers

PMID: 8094373
DOI: 10.1006/geno.1993.1006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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