Article
[Analysis of HLA-DR, -DQA1, -DQB1 genes in Japanese IDDM patients].
Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 1994
Maruyama T
Abstract excerpt
Susceptibility to insulin-dependent diabetes mellitus (IDDM) is determined by both genetic and environmental factors. The major genetic susceptibility to IDDM is conferred by genes in the HLA class II region on chromosome 6. In Caucasians, this susceptibility is thought to be determined by DQA1 and DQB1 genes including the presence of arginine at position 52 of the DQ alpha chain and the absence of aspartic acid...
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