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Article

Infection of Cells with Varicella‐Zoster Virus Down‐Regulates Surface Expression of Class I Major Histocompatibility Complex Antigens

1 May 1998

Abstract excerpt

In vitro assays indicate that both major histocompatibility complex (MHC) class I and II-restricted cytotoxic T lymphocytes are important for recognition of varicella-zoster virus (VZV)-infected cells. This study demonstrates that infection of human fibroblasts with wild-type or recombinant-derived strain Oka VZV results in down-regulation of surface expression of class I MHC heavy chains. Radioactive labeling of...

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PMID: 9593031
DOI: 10.1086/517821

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Related research

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Infection of Cells with Varicella‐Zoster Virus Down‐Regulates Surface Expression of Class I Major Histocompatibility Complex AntigensPMID 9593031Read ↗

Down-regulation of the class I HLA heterodimer and beta2-microglobulin on the surface of cells infected with cytomegalovirusSemantic proximity Read ↗

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The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particlesSemantic proximity Read ↗

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Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.Semantic proximity Read ↗

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