Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.

Cancer immunology, immunotherapy : CII - 1 Jan 1992

Leon J A, Gutierrez M C, Jiang H, Estabrook A, Waxman S, Fisher P B

Abstract excerpt

In the present study we have analyzed the effect of a synthetic protein kinase C (PKC) activator 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol (ADMB) and the natural PKC-activating tumor-promoting agents 12-O-tetradecanoylphorbol 13-acetate (TPA) and mezerein on the antigenic phenotype of T47D human breast carcinoma cells. All three agents increased the surface expression of the tumor-associated...

Topics

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Benzyl Alcohols
Breast Neoplasms
Carcinoma
Cell Adhesion Molecules
Cell Division
Diterpenes
Female
Glycoproteins
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Intercellular Adhesion Molecule-1

Interferon Type I

Interferon-gamma

Isoquinolines

Phenotype

Piperazines

Protein Kinase C

Source

Open in PubMed Open full text

Identifiers

PMID: 1356626
DOI: 10.1007/BF01741144
PMCID: PMC11038698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1356626-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.PMID 1356626Read ↗

Recombinant human leukocyte interferon induces alterations in the antigen phenotype of human breast carcinoma cells.Semantic proximity Read ↗

Regulation of the antigenic phenotype of human melanoma cells by recombinant interferons.Semantic proximity Read ↗

Effects of differentiation inducers on cell phenotypes of cultured nontransformed and immortalized mammary epithelial cells: a comparative immunocytochemical analysis.Semantic proximity Read ↗

Protein kinase C and its isoforms in human breast cancer cells: relationship to the invasive phenotype.Semantic proximity Read ↗

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.Semantic proximity Read ↗

Biochemical and immunological phenotype alterations in human monoblastoid cell line U-937 induced by physiological (interferon-alpha, retinoic acid) and nonphysiological (phorbol ester) inducers.Semantic proximity Read ↗

Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression.Semantic proximity Read ↗

Effects of differentiating agents on cell surface expression of the breast carcinoma-associated DF3-P epitope.Semantic proximity Read ↗

Modulation of the antigenic phenotype of early-passage human melanoma cells derived from multiple autologous metastases by recombinant human leukocyte, fibroblast and immune interferon.Semantic proximity Read ↗

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines.Semantic proximity Read ↗

Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content.Semantic proximity Read ↗

Comparative analysis of the effects of dimethyl sulfoxide and retinoic acid on the antigenic pattern of human ovarian adenocarcinoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.