Article
Modulation of the antigenic phenotype of early-passage human melanoma cells derived from multiple autologous metastases by recombinant human leukocyte, fibroblast and immune interferon.
International journal of cancer - 15 Sept 1990
Giacomini P, Fraioli R, Nistico P, Tecce R, Nicotra M R, Di Filippo F, Fisher P B, Natali P G
Abstract excerpt
We have investigated the relationship between in vitro cultivation of autologous melanoma metastases derived from different patients and their levels of expression of class-I and -II major histocompatibility complex (MHC) antigens and melanoma-associated antigens (MAAs). Cell cultures were established from 23 individual metastatic melanoma lesions from 10 patients and were tested early after isolation (between...
Topics
- Antigens, Neoplasm
- Enzyme-Linked Immunosorbent Assay
- HLA Antigens
- Humans
- Interferon Type I
- Interferon-gamma
- Melanoma
- Neoplasm Metastasis
- Phenotype
- Recombinant Proteins