Article
Regulation of the antigenic phenotype of human melanoma cells by recombinant interferons.
Anticancer research - 1 Jan 2000
Giacomini P, Gambari R, Barbieri R, Nisticò P, Tecce R, Pestka S, Gustafsson K, Natali P G, Fisher P B
Abstract excerpt
The ability of interferons to modulate the antigenic phenotype of tumor cells may involve alterations in the transcription, translation, membrane expression and shedding of Major Histocompatibility Complex (MHC) and Tumor Associated Antigens (TAAs). In the present study we have investigated possi...
Topics
- Antigens, Neoplasm
- Cell Line
- Gene Expression Regulation
- Humans
- Interferon Type I
- Interferon-gamma
- Interferons
- Major Histocompatibility Complex
- Melanoma
- Melanoma-Specific Antigens
- Neoplasm Proteins
- Phenotype
- RNA, Messenger
- Recombinant Proteins
- Time Factors