Article
Regulation of the antigenic phenotype of human melanoma cells by recombinant interferons.
Anticancer research - 1 Jan 2000
Giacomini P, Gambari R, Barbieri R, Nisticò P, Tecce R, Pestka S, Gustafsson K, Natali P G, Fisher P B
Abstract excerpt
The ability of interferons to modulate the antigenic phenotype of tumor cells may involve alterations in the transcription, translation, membrane expression and shedding of Major Histocompatibility Complex (MHC) and Tumor Associated Antigens (TAAs). In the present study we have investigated possible mechanisms by which recombinant human interferons, IFN-alpha, -beta and -gamma, alter the antigenic profile of...
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