Article
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.
Lancet (London, England) - 22 Aug 1992
Velho G, Froguel P, Clement K, Pueyo M E, Rakotoambinina B, Zouali H, Passa P, Cohen D, Robert J J
Abstract excerpt
Maturity-onset diabetes of the young (MODY), characterised by non-insulin-dependent diabetes mellitus (NIDDM) with an early age of onset, is a genetically heterogeneous disorder. In most MODY kindreds described in France, chronic hyperglycaemia is caused by mutations in the gene encoding pancreat...
Topics
- Adolescent
- Adult
- Blood Glucose
- C-Peptide
- Diabetes Mellitus, Type 2
- Evaluation Studies as Topic
- Female
- Genetic Linkage
- Glucokinase
- Glucose Tolerance Test
- Humans
- Insulin
- Insulin Secretion
- Male
- Middle Aged
- Mutation