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Article

Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.

Lancet (London, England) - 22 Aug 1992

Velho G, Froguel P, Clement K, Pueyo M E, Rakotoambinina B, Zouali H, Passa P, Cohen D, Robert J J

Abstract excerpt

Maturity-onset diabetes of the young (MODY), characterised by non-insulin-dependent diabetes mellitus (NIDDM) with an early age of onset, is a genetically heterogeneous disorder. In most MODY kindreds described in France, chronic hyperglycaemia is caused by mutations in the gene encoding pancreatic beta-cell and liver glucokinase (GCK). We here report the beta-cell secretory profiles of nine patients from four...

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Identifiers

PMID: 1354782
DOI: 10.1016/0140-6736(92)91768-4

Genes

GCK

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.PMID 1354782Read ↗

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Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.Semantic proximity Read ↗

Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor.Semantic proximity Read ↗

Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.Semantic proximity Read ↗

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