Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.

doi:10.2337/diab.46.2.204

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Article

Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.

Diabetes - 1 Feb 1997

Tappy L, Dussoix P, Iynedjian P, Henry S, Schneiter P, Zahnd G, Jéquier E, Philippe J

Abstract excerpt

A subtype of maturity-onset diabetes of the young (MODY) is caused by mutations of the glucokinase gene, an enzyme expressed in pancreatic beta-cells and the liver. To assess the consequences of a functional alteration of glucokinase at the level of the liver, endogenous (hepatic) glucose product...

Topics

Adult
Blood Glucose
C-Peptide
Calorimetry
Diabetes Mellitus, Type 2
Female
Glucokinase
Glucose
Humans
Insulin
Liver
Male
Middle Aged
Mutation
Oxidation-Reduction

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