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Article

Assessment of insulin sensitivity in glucokinase-deficient subjects.

Diabetologia - 1 Jan 1996

Clément K, Pueyo M E, Vaxillaire M, Rakotoambinina B, Thuillier F, Passa P, Froguel P, Robert J J, Velho G

Abstract excerpt

The chronic hyperglycaemia of glucokinase-deficient diabetes results from a glucose-sensing defect in pancreatic beta cells and abnormal hepatic glucose phosphorylation. We have evaluated the contribution of insulin resistance to this form of chronic hyperglycaemia. Insulin sensitivity, assessed by the homeostasis model assessment (HOMA) method in 35 kindreds with glucokinase mutations, was found to be...

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PMID: 8720607
DOI: 10.1007/BF00400417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Assessment of insulin sensitivity in glucokinase-deficient subjects.PMID 8720607Read ↗

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Glucokinase mutations, insulin secretion, and diabetes mellitus.Semantic proximity Read ↗

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Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.Semantic proximity Read ↗

Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of diseaseSemantic proximity Read ↗

Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds.Semantic proximity Read ↗

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.Semantic proximity Read ↗

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