Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.

doi:10.1016/j.immuni.2006.08.018

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Article

Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.

Immunity - 1 Oct 2006

Gangadharan Denise, Lambolez Florence, Attinger Antoine, Wang-Zhu Yiran, Sullivan Barbara A, Cheroutre Hilde

Abstract excerpt

The immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted to preferentially give rise to CD8alphaalpha(+)TCRalphabeta(+) IELs, but they required exposure...

Topics

Animals
CD4 Antigens
CD8 Antigens
Cell Differentiation
Cytokines
Intestinal Mucosa
Lymphocyte Activation
Mice
Mice, Inbred Strains
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 17045820
DOI: 10.1016/j.immuni.2006.08.018

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