Article
Microsatellite instability and K-ras mutations in patients with ulcerative colitis.
Human pathology - 1 Jun 2000
Lyda M H, Noffsinger A, Belli J, Fenoglio-Preiser C M
Abstract excerpt
Patients with inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), have an increased incidence of colorectal carcinoma. The underlying mechanism is unknown, but we postulated that microsatellite instability (MSI) might predispose the colonic mucosa of UC patients to mutations, thereby increasing their cancer risk. We also sought to determine the frequency of K-ras mutations, to determine...
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