Article
The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.
Genes & development - 1 Mar 1993
Zhao J J, Lazzarini R A, Pick L
Abstract excerpt
To test whether the mouse Hox-1.3 gene is a cognate of the Drosophila Sex combs reduced (Scr) gene, we inserted a hsp 70-Hox-1.3 fusion gene into the Drosophila genome. Transgenic flies displayed Scr-like homeotic transformations after ectopic expression of Hox-1.3 induced by heat shock. In larva...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Base Sequence
- Drosophila
- Embryo, Nonmammalian
- Gene Expression
- Gene Expression Regulation
- Genes, Homeobox
- Heat-Shock Proteins
- Hot Temperature
- Larva
- Mice
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Open Reading Frames
- Phenotype
- Recombinant Fusion Proteins