Article
The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans.
Journal of neurochemistry - 1 Apr 1992
Hosono R, Hekimi S, Kamiya Y, Sassa T, Murakami S, Nishiwaki K, Miwa J, Taketo A, Kodaira K I
Abstract excerpt
Genes affecting acetylcholine (ACh) levels without influencing choline acetyltransferase activity have been identified in Caenorhabditis elegans. We have examined one such gene, unc-18. We isolated a transposon-insertion allele for unc-18 and used it to clone a genomic region containing the unc-1...
Topics
- Acetylcholine
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis
- Cloning, Molecular
- DNA
- Genes
- Kinetics
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymorphism, Restriction Fragment Length
- Proteins
- Transcription, Genetic
- Transformation, Genetic