Article
Alteration in cellular acetylcholine influences dauer formation in Caenorhabditis elegans.
BMB reports - 1 Feb 2014
Lee Jeeyong, Kim Kwang-Youl, Paik Young-Ki
Abstract excerpt
Altered acetylcholine (Ach) homeostasis is associated with loss of viability in flies, developmental defects in mice, and cognitive deficits in human. Here, we assessed the importance of Ach in Caenorhabditis elegans development, focusing on the role of Ach during dauer formation. We found that dauer formation was disturbed in choline acetyltransferase (cha-1) and acetylcholinesterase (ace) mutants defective in...
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