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Article

Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 1994

Alfonso A, Grundahl K, McManus J R, Rand J B

Abstract excerpt

We have cloned the cha-1 gene from Caenorhabditis elegans using the method of transposon tagging, cha-1 is the structural gene for ChAT, the enzyme that synthesizes ACh. Sequence analysis of cDNAs predicts a protein of 71.5 kDa; comparison of the deduced amino acid sequence with ChAT sequences from other species confirms that cha-1 encodes ChAT. Comparison of cDNA and genomic sequences reveals that transcription...

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Identifiers

PMID: 8158270
PMCID: PMC6577154

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