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Article

A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 1996

Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y

Abstract excerpt

Caenorhabditis elegans UNC-18 protein, homologous to yeast Sec1p, is important in neurotransmitter release, because the unc-18 mutation leads to severe paralysis and presynaptic acetylcholine (ACh) accumulation. To examine the functional conservation in mammals, we tried to isolate unc-18 isoforms from mouse and human brain cDNA libraries and obtained two classes of isoforms-neural genes and ubiquitous genes....

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PMID: 8824310
PMCID: PMC6579271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.PMID 8824310Read ↗

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