Article
A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 1996
Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y
Abstract excerpt
Caenorhabditis elegans UNC-18 protein, homologous to yeast Sec1p, is important in neurotransmitter release, because the unc-18 mutation leads to severe paralysis and presynaptic acetylcholine (ACh) accumulation. To examine the functional conservation in mammals, we tried to isolate unc-18 isoform...
Topics
- Animals
- Animals, Genetically Modified
- Antibody Specificity
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Carrier Proteins
- Cholinergic Fibers
- Cloning, Molecular
- Genetic Complementation Test
- Helminth Proteins
- Humans
- Mice
- Molecular Sequence Data
- Munc18 Proteins
- Mutation
- Nerve Tissue Proteins
- Neurotransmitter Agents