Mutations in the unc-41 gene cause elevation of acetylcholine levels.

doi:10.1046/j.1471-4159.1994.63020439.x

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Article

Mutations in the unc-41 gene cause elevation of acetylcholine levels.

Journal of neurochemistry - 1 Aug 1994

Harada S, Hori I, Yamamoto H, Hosono R

Abstract excerpt

Mutations in the Caenorhabditis elegans unc-41 gene result in an allele-dependent elevation of acetylcholine content. Eight recessive alleles (cn252, e268, e399, e650, e1175, e1199, e1294, and e870) lead to phenotypes including uncoordinated locomotion, slow growth, a small mature body, and resis...

Topics

Acetylcholine
Acetylcholinesterase
Alleles
Animals
Caenorhabditis elegans
Choline O-Acetyltransferase
Crosses, Genetic
Disorders of Sex Development
Genetic Complementation Test
Male
Motor Activity
Mutation
Suppression, Genetic
Synaptic Vesicles

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