Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonrandom chromosome losses in tumorigenic revertants of hybrids between isogeneic immortal and neoplastic human uroepithelial cells.

Somatic cell and molecular genetics - 1 Nov 1991

Klingelhutz A J, Wu S Q, Reznikoff C A

Abstract excerpt

Somatic cell hybrid analysis was used to examine the role of recessive cancer genes in tumorigenic transformation in vitro of human uroepithelial cells (HUC). Hybrids between nontumorigenic pseudodiploid SV40-immortalized HUC (SV-HUC) and two aggressive grade III transitional cell carcinomas (TCC) produced in nude mice after in vitro exposure of SV-HUC to 3-methylcholanthrene (MC) were completely suppressed for...

Topics

Carcinoma, Transitional Cell
Cell Line, Transformed
Cell Transformation, Neoplastic
Chromosome Deletion
Crosses, Genetic
Epithelial Cells
Humans
Hybrid Cells
Karyotyping
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 1767334
DOI: 10.1007/BF01233620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1767334-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonrandom chromosome losses in tumorigenic revertants of hybrids between isogeneic immortal and neoplastic human uroepithelial cells.PMID 1767334Read ↗

Allelic 3p deletions in high-grade carcinomas after transformation in vitro of human uroepithelial cells.Semantic proximity Read ↗

Neoplastic progression by EJ/ras at different steps of transformation in vitro of human uroepithelial cells.Semantic proximity Read ↗

Genetic analysis of an in vitro model system for human papillomavirus type 16-associated tumorigenesis.Semantic proximity Read ↗

Chromosomal changes in uroepithelial carcinomasSemantic proximity Read ↗

Stepwise genetic changes associated with progression of nontumorigenic HPV-18 immortalized human prostate cancer-derived cell line to a malignant phenotype.Semantic proximity Read ↗

Genetics of transitional cell carcinoma.Semantic proximity Read ↗

Analysis of somatic cell hybrids derived from normal human prostatic epithelial cells fused with HeLa cells.Semantic proximity Read ↗

Suppression of malignant phenotype in a human prostate cancer cell line by fragments of normal chromosomal region 17q.Semantic proximity Read ↗

Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes.Semantic proximity Read ↗

Accumulated allelic losses in the development of invasive urothelial cancer.Semantic proximity Read ↗

Simian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells.Semantic proximity Read ↗

The Relationship Between Spontaneous Telomere Loss and Chromosome Instability in a Human Tumor Cell LineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.