Article
Current status of adjuvant chemotherapy for colorectal cancer. Can molecular markers play a role in predicting prognosis?
Cancer - 15 Sept 1992
O'Connell M J, Schaid D J, Ganju V, Cunningham J, Kovach J S, Thibodeau S N
Abstract excerpt
BACKGROUND: Recent clinical trials establish a beneficial effect for adjuvant chemotherapy after surgical resection of the primary tumor (1) as single treatment for patients with colonic cancer and (2) combined with radiation therapy for patients with rectal cancer. Because adjuvant chemotherapy is not universally effective and is associated with toxicity and some degree of risk, it would be desirable to...
Topics
- Aged
- Biomarkers, Tumor
- Chemotherapy, Adjuvant
- Chromosomes, Human, Pair 17
- Colorectal Neoplasms
- Combined Modality Therapy
- Female
- Genes, Tumor Suppressor
- Humans
- Male
- Mutation