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Article

A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics.

Cancer research - 1 Feb 2001

Wakita K, Tetsu O, McCormick F

Abstract excerpt

Colon cancer cells frequently lose expression of the tumor suppressor adenomatous polyposis coli (APC). As result, beta-catenin accumulates and activates transcription of Tcf-responsive genes. Here we describe a novel mammalian two-hybrid system that selectively kills APC-mutated cells. This system consists of GAL4/beta-catenin, VP16/Tcf4, and a gene that is transcribed when GAL4 and VP16 associate. In...

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Source

Identifiers

PMID: 11221869

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APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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