Article
Identification of the minimum requirements for successful haematopoietic stem cell transplantation.
British journal of haematology - 1 Feb 2022
Nishi Katsuyuki, Sakamaki Taro, Sadaoka Kay, Fujii Momo, Takaori-Kondo Akifumi, Chen James Y, Miyanishi Masanori
Abstract excerpt
Historically, defining haematopoietic subsets, including self-renewal, differentiation and lineage restriction, has been elucidated by transplanting a small number of candidate cells with many supporting bone marrow (BM) cells. While this approach has been invaluable in characterising numerous distinct subsets in haematopoiesis, this approach is arguably flawed. The haematopoietic stem cell (HSC) has been...
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