Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells

19 Mar 2012

Abstract excerpt

The question of whether a single hematopoietic stem cell (HSC) gives rise to all of the B-cell subsets [B-1a, B-1b, B-2, and marginal zone (MZ) B cells] in the mouse has been discussed for many years without resolution. Studies here finally demonstrate that individual HSCs sorted from adult bone marrow and transferred to lethally irradiated recipients clearly give rise to B-2, MZ B, and B-1b, but does not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22431624
DOI: 10.1073/pnas.1121632109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cellsPMID 22431624Read ↗

Stem Cells, Hematopoiesis and Lineage Tracing: Transplantation-Centric Views and BeyondSemantic proximity Read ↗

Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte CompartmentSemantic proximity Read ↗

Embryonic Origins of the Hematopoietic System: Hierarchies and HeterogeneitySemantic proximity Read ↗

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cellsSemantic proximity Read ↗

Stem cell heterogeneity: implications for aging and regenerative medicineSemantic proximity Read ↗

The influence of developmental timing on B cell diversity.Semantic proximity Read ↗

Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level?Semantic proximity Read ↗

B Cell Development PathwaysSemantic proximity Read ↗

Ontogeny of human B1 cells.Semantic proximity Read ↗

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell CompartmentSemantic proximity Read ↗

The emergence of definitive hematopoietic stem cells in the mammalSemantic proximity Read ↗

Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.