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Article

Virulence of non-type 1-fimbriated and nonfimbriated nonflagellated Salmonella typhimurium mutants in murine typhoid fever.

Infection and immunity - 1 Feb 1992

Lockman H A, Curtiss R

Abstract excerpt

The virulence of Salmonella typhimurium mutants that were unable to synthesize type 1 fimbriae was tested in a murine typhoid fever model. Nonfimbriated mutants (fim) exhibited a lower 50% lethal dose than a wild-type (fim+) strain and produced significantly higher mortality (fim, 55%; fim+, 37% [P less than 0.002]) in mice that were challenged orally. There was no difference in virulence when the wild-type and...

Topics

Animals
Female
Fimbriae, Bacterial
Flagella
Mice
Mice, Inbred BALB C
Mutation
Salmonella Infections, Animal
Salmonella typhimurium
Typhoid Fever
Virulence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1346124
DOI: 10.1128/iai.60.2.491-496.1992
PMCID: PMC257654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1346124-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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