At least four percent of the Salmonella typhimurium genome is required for fatal infection of mice.

doi:10.1128/IAI.66.7.3372-3377.1998

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Article

At least four percent of the Salmonella typhimurium genome is required for fatal infection of mice.

Infection and immunity - 1 Jul 1998

Bowe F, Lipps C J, Tsolis R M, Groisman E, Heffron F, Kusters J G

Abstract excerpt

Salmonella typhimurium infection of mice is an established model system for studying typhoid fever in humans. Using this model, we identified S. typhimurium genes which are absolutely required to cause fatal murine infection by testing independently derived transposon insertion mutants for loss o...

Topics

Animals
DNA Transposable Elements
Female
Genome, Bacterial
Mice
Mice, Inbred BALB C
Mutation
Salmonella Infections, Animal
Salmonella typhimurium
Virulence

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