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Article

At least four percent of the Salmonella typhimurium genome is required for fatal infection of mice.

Infection and immunity - 1 Jul 1998

Bowe F, Lipps C J, Tsolis R M, Groisman E, Heffron F, Kusters J G

Abstract excerpt

Salmonella typhimurium infection of mice is an established model system for studying typhoid fever in humans. Using this model, we identified S. typhimurium genes which are absolutely required to cause fatal murine infection by testing independently derived transposon insertion mutants for loss of virulence in vivo. Of the 330 mutants tested intraperitoneally and the 197 mutants tested intragastrically, 12...

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Identifiers

PMID: 9632607
DOI: 10.1128/IAI.66.7.3372-3377.1998
PMCID: PMC108354

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