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Article

Synergistic effect of mutations in invA and lpfC on the ability of Salmonella typhimurium to cause murine typhoid.

Infection and immunity - 1 Jun 1997

Bäumler A J, Tsolis R M, Valentine P J, Ficht T A, Heffron F

Abstract excerpt

Penetration of the intestinal mucosa at areas of Peyer's patches is an important first step for Salmonella typhimurium to produce lethal systemic disease in mice. However, mutations in genes that are important for intestinal invasion result in only moderately decreased virulence of S. typhimurium for mice. Here we report that combining mutations in invA and lpfC, two genes necessary for entry into Peyer's...

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Identifiers

PMID: 9169760
DOI: 10.1128/iai.65.6.2254-2259.1997
PMCID: PMC175312

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