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Article

Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype.

Journal of bacteriology - 1 Jan 1994

Schmitt C K, Darnell S C, Tesh V L, Stocker B A, O'Brien A D

Abstract excerpt

Salmonella typhimurium ST39 exhibits reduced virulence in mice and decreased survival in mouse macrophages compared with the parent strain SL3201. Strain ST39 is nonmotile, carries an indeterminate deletion in and near the flgB operon, and is defective in the mviS (mouse virulence Salmonella) locus. In flagellum-defective strains, the flgM gene product of S. typhimurium negatively regulates flagellar genes by...

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Identifiers

PMID: 8288531
DOI: 10.1128/jb.176.2.368-377.1994
PMCID: PMC205059

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