Article
Absence of all components of the flagellar export and synthesis machinery differentially alters virulence of Salmonella enterica serovar Typhimurium in models of typhoid fever, survival in macrophages, tissue culture invasiveness, and calf enterocolitis.
Infection and immunity - 1 Sept 2001
Schmitt C K, Ikeda J S, Darnell S C, Watson P R, Bispham J, Wallis T S, Weinstein D L, Metcalf E S, O'Brien A D
Abstract excerpt
In this study, we constructed an flhD (the master flagellar regulator gene) mutant of Salmonella enterica serovar Typhimurium and compared the virulence of the strain to that of the wild-type strain in a series of assays that included the mouse model of typhoid fever, the mouse macrophage survival assay, an intestinal epithelial cell adherence and invasion assay, and the calf model of enterocolitis. We found that...
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