Article
Germline large genomic alterations on 7q in patients with multiple primary cancers.
Scientific reports - 31 Jan 2017
Villacis R A R, Basso T R, Canto L M, Nóbrega A F, Achatz M I, Rogatto S R
Abstract excerpt
Patients with multiple primary cancers (MPCs) are suspected to have a hereditary cancer syndrome. However, only a small proportion may be explained by mutations in high-penetrance genes. We investigate two unrelated MPC patients that met Hereditary Breast and Ovaria Cancer criteria, both presenting triple negative breast tumors and no mutations in BRCA1, BRCA2 and TP53 genes. Germline rearrangements on chromosome...
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